Long-term equine groove model study
The contents of this datapackage are required to analyse and reproduce the results of the publication 'Structural, compositional, and functional effects of blunt and sharp cartilage damage on the joint: a 9-month equine cartilage groove model' DOI: https://doi.org/10.1002/jor.24971 The aim of that study was to quantify the long-term progression of blunt and sharp cartilage defects and their effect on joint homeostasis and function of the equine carpus. In nine adult Shetland ponies, the cartilage in the radiocarpal and middle carpal joint of one front limb was grooved (blunt or sharp randomized). The ponies were subjected to an 8-week exercise protocol and sacrificed at 39 weeks. Structural and compositional alterations in joint tissues were evaluated in vivo using serial radiographs, synovial biopsies, and synovial fluid samples. Joint function was monitored by quantitative gait analysis. Macroscopic, microscopic, and biomechanical evaluation of the cartilage, and assessment of subchondral bone parameters (micro-CT) were performed ex vivo.
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